ECAI 2004 Conference Paper

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Gene Network Modeling through Semi-Fixed Bayesian Network

Tie-Fei Liu, Wing-Kin Sung, Ankush Mittal

Gene networks describe functional pathways in a given cell or tissue, representing processes such as metabolism, gene expression regulation, protein or RNA transport. Thus, learning gene network is a crucial problem in the post genome era. Most existing works learn gene networks by assuming one gene provokes the expression of another gene directly leading to an over-simplified model. In this paper, we show that the gene regulation is a complex problem with many hidden variables. We propose a semi-fixed model to represent the gene network as a Bayesian network with hidden variables. In addition, an effective algorithm to learn the model is presented. Experiments on artificial and real-life dataset confirm the effectiveness of our approach.

Keywords: Semi-Fix Network, Bayesian Network, Gene Network

Citation: Tie-Fei Liu, Wing-Kin Sung, Ankush Mittal: Gene Network Modeling through Semi-Fixed Bayesian Network. In R.López de Mántaras and L.Saitta (eds.): ECAI2004, Proceedings of the 16th European Conference on Artificial Intelligence, IOS Press, Amsterdam, 2004, pp.373-377.

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ECAI-2004 is organised by the European Coordinating Committee for Artificial Intelligence (ECCAI) and hosted by the Universitat Politècnica de València on behalf of Asociación Española de Inteligencia Artificial (AEPIA) and Associació Catalana d'Intel-ligència Artificial (ACIA).